Modalert 100 mg tablet is an effective drug that can be used to treat narcolepsy. This medication reduces excessive sleepiness by stimulating the brain and acting as a wakefulness-promoting agent. It also helps to improve cognitive function. It is important to take this medicine regularly and at the prescribed time.

The effects of Modalert vary from person to person. Some people experience heart pounding or nervousness while others experience a rash.

Dopamine

Dopamine is a neurotransmitter involved in alertness, motivation, attention, and movement. Modalert enhances spatial WM in the rat with a dose-dependent effect (Figure 6C-F). It also modulates hippocampal D1R, D2R and D3R, DAT, and pDAT protein levels (Figure 5) showing a correlation between D1-D3-CC and D2R-CC with a stronger relation to D2R-CC. It decreases [11C]raclopride BPND in the caudate, putamen and nucleus accumbens probably reflecting increases in dopamine concentration due to inhibition of dopamine reuptake. It also decreases [11C]cocaine BPND in the nucleus accumbens possibly related to its anti-opioid activity. Figure 5 BN-PAGE Western blot images of hippocampal membrane fractions with D1R, D2R, D3R, DAT, and pDAT CC.

Serotonin

Modalert 100 mg interacts with serotonin through its inhibition of the reuptake of this neurotransmitter. This is an important activity because serotonin has been associated with several adverse cardiovascular effects such as fibrosis of cardiac valves, constriction of coronary blood vessels, arrhythmias, and thrombosis. In addition, it increases resting systolic and diastolic blood pressure in some people. Serotonin also stimulates the secretion of aldosterone and renin, which further increases blood pressure. Therefore, Modalert is a useful medication for patients with mild to severe hypertension.

GABA

Modalert 100 mg tablet increases both spontaneous and electrically evoked (5HT) efflux in the frontal cortex, but does not affect basal or K+-evoked release of GABA (Antonelli et al, 1995). This effect could be mediated by adrenergic effects on 5HT activity and/or by inhibition of DAT. Alternatively, Modvigil Australia could exert its cognitive effects by enhancing cortical acetylcholine. In contrast to fenfluramine, which enhances both HA effects and cortical acetylcholine, Modalert does not significantly affect 5HT uptake in cultured cortical synaptosomes. However, it does prevent the inhibitory effect of glutamate on the reduction of GABA release from these cells.